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In 2025, the narrative of "AI investing" has shifted from speculative curiosity to a fundamental requirement for growth portfolios. With AI spending expected to surpass $2 trillion by 2026, investors are no longer asking *if* they should invest, but *how*.
This guide breaks down the winning strategies that institutional and retail investors are using to outperform the S&P 500 this year.
A "Pure Play" strategy involves investing in companies whose primary revenue and value proposition are derived directly from AI development. These are the "First Movers."
As the "Big Tech" hyperscalers (Amazon, Microsoft, Google) look to reduce their dependence on standard GPUs, a new opportunity has emerged in Custom AI Accelerators.
Investing in the hardware that enables AI is often seen as a safer "picks and shovels" approach. In 2025, Micron Technology (MU) and Broadcom (AVGO) have significantly outperformed the broader tech sector by providing the networking and memory essential for AI data centers.
This strategy focuses on traditional companies that are using AI to revolutionize their own margins. These are often non-tech companies in sectors like finance, healthcare, and retail.
| Sector | AI Application | Example Stocks |
|---|---|---|
| Finance | Algorithmic Risk Assessment | JPMorgan, Visa |
| Retail | Autonomous Inventory | Walmart, Amazon |
| Healthcare | AI Drug Discovery | Eli Lilly, Moderna |
The "Next Big Thing" is Agentic AI—autonomous systems that can execute multi-step tasks (like managing an entire marketing campaign or auditing a tax return) without human intervention. Analysts expect this niche to grow at a CAGR of 175% through 2029.
Watchlist for 2026: Look at Salesforce (CRM) and its Agentforce initiative, as well as Meta Platforms (META) for their work in open-source AI agents for small businesses.
For those who prefer a "set it and forget it" approach, Exchange-Traded Funds (ETFs) provide broad exposure while mitigating the risk of a single company failing.
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